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中华胃食管反流病电子杂志 ›› 2020, Vol. 07 ›› Issue (01) : 64 -67. doi: 10.3877/ cma.j.issn.2095-8765.2020.01.008

所属专题: 文献

综述

胃肠道间质瘤的免疫疗法现状与进展
帕尔哈提江·阿布力米提1, 多力坤·牙生1, 克力木·阿不都热依木1,(), 阿巴伯克力·乌斯曼1   
  1. 1. 830001 乌鲁木齐,新疆维吾尔自治区人民医院微创、疝和腹壁外科
  • 收稿日期:2019-07-22 出版日期:2020-02-15
  • 通信作者: 克力木·阿不都热依木
  • 基金资助:
    新疆维吾尔自治区自然科学基金(2018D01C115)

Current status and progression of immunotherapy for gastrointestinal stromal tumor

Paerhatijiang·Abulimiti1, Duolikun·Yasheng1, Kelimu·Abudureyimu1,(), . Ababokeli·Wusiman1   

  1. 1. Department of Minimally Invasive Surgery & Hernia and Abdominal Wall Surgery, People's Hospital of Xinjiang Uygur Autonomus Region, Urmuqi 830001, China
  • Received:2019-07-22 Published:2020-02-15
  • Corresponding author: Kelimu·Abudureyimu
  • About author:
    Corresponding author: Kelimu·Abudureyimu, Email:
引用本文:

帕尔哈提江·阿布力米提, 多力坤·牙生, 克力木·阿不都热依木, 阿巴伯克力·乌斯曼. 胃肠道间质瘤的免疫疗法现状与进展[J/OL]. 中华胃食管反流病电子杂志, 2020, 07(01): 64-67.

Paerhatijiang·Abulimiti, Duolikun·Yasheng, Kelimu·Abudureyimu, . Ababokeli·Wusiman. Current status and progression of immunotherapy for gastrointestinal stromal tumor[J/OL]. Chinese Journal of Gastroesophageal Reflux Disease(Electronic Edition), 2020, 07(01): 64-67.

胃肠道间质瘤是胃肠道最常见的良性间叶源性肿瘤。在我国发病率较高,因在疾病早期临床症状缺乏特异性、极易恶变、易产生药物耐药、术后复发率较高以及对化疗、放疗不敏感,严重影响着患者的生活质量。免疫疗法是新兴的精准、快速、安全及高效的诊疗方法。本文中笔者对国内外胃肠道间质瘤的免疫疗法的相关主要观点进行综述,旨为进一步探究其作用机制以及临床推广奠定理论基础。

Gastrointestinal stromal tumor (GIST) is the most common benign mesenchymal tumor of the gastrointestinal tract. It has a high incidence in China. Because of the lack of specificity in the early stage of the disease, it is highly susceptible to malignant transformation and is prone to drug resistance. The high recurrence rate and insensitivity to chemoradiation are increasingly affecting the quality of life of patients. Immunotherapy is an emerging method for precise, rapid, safe and efficient diagnosis and treatment. It is currently used to treat a variety of tumors such as melanoma, non-small cell lung cancer, kidney cancer and prostate cancer, and has achieved satisfactory results. This article aims to summarize the main points of immunotherapy related to gastrointestinal stromal tumors at home and abroad, in order to further study its mechanism of action and lay a theoretical foundation for larger clinical trials.

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